A Single-Cell Atlas of Synovial Aging
Our dataset provides the first high-resolution single-cell transcriptomic map of the murine synovium comparing young (2-3 months) and aged (18-22 months) mice.
You can explore the full dataset to explore cell populations, gene expression, and age-related changes through our interactive UCSC Cell Browser:
Launch the Synovial Aging Atlas
About the study
This study provides a detailed cellular map of the murine synovium during physiological aging, revealing selective loss and dysfunction of sublining fibroblasts and resident macrophages that together drive fibrosis independently of inflammation. These findings offer new insight into age-related joint vulnerability and open avenues for therapeutic strategies targeting tissue homeostasis.
A link to the full publication will be made available here upon release.
We aim to provide a foundational reference for joint aging studies and therapeutic targeting beyond inflammation.
Contact
Olivier Bortolotti
Institute of Regenerative Medicine and Biotherapy (IRMB)
University of Montpellier, INSERM U1183
80 rue Augustin Fliche, 34295 Montpellier, France
Email: olivier.bortolotti@inserm.fr
Phone: +33 4 67 33 56 99
Gabriel Courties, PhD
Institute of Regenerative Medicine and Biotherapy (IRMB)
University of Montpellier, INSERM U1183
80 rue Augustin Fliche, 34295 Montpellier, France
Email: gabriel.courties@inserm.fr
Phone: +33 4 67 33 05 05
Florence Apparailly, PhD
Institute of Regenerative Medicine and Biotherapy (IRMB)
University of Montpellier, INSERM U1183
80 rue Augustin Fliche, 34295 Montpellier, France
Email: florence.apparailly@inserm.fr
Phone: +33 4 67 33 56 96
Data availability
Data on GEO
GSE299534